Can Donating Plasma Cause Erectile Dysfunction



Donating plasma is a life-saving act that allows plasma donation centers to make plasma-derived therapies for patients with rare and serious diseases. However, some myths have emerged about possible negative health effects from donating plasma, including that it may cause erectile dysfunction. In this article, we explore the facts behind this commonly cited myth and provide evidence to reassure plasma donors about the safety of the plasma donation process.

What is Erectile Dysfunction?

Erectile dysfunction (ED), commonly known as impotence, is the inability to get or maintain an erection firm enough for sexual intercourse. ED can be caused by both physical and psychological factors, including:

  • Age: As men get older, they are more prone to developing ED. This is due to natural age-related changes like decreased testosterone levels and blood flow.
  • Medical conditions: Chronic health issues such as diabetes, heart disease, obesity, and high blood pressure can contribute to ED.
  • Medications: Many common medications like antidepressants, antihistamines, blood pressure medications, and chemotherapy drugs list ED as a potential side effect.
  • Psychological factors: Stress, anxiety, depression, and relationship issues may also play a role in ED. For some men, ED may be due to a combination of physical and psychological factors.
  • Hormone levels: Low testosterone (low T) can lead to symptoms like decreased libido, erectile difficulties, and mood changes.
  • Lifestyle factors: Lifestyle choices such as smoking, alcohol abuse, and lack of physical activity can also increase the risk of ED.

ED is a complex medical issue that affects as many as 30 million men in the United States. The cause is often multi-faceted, and the best form of treatment depends on the underlying factors contributing to ED for each individual.

The Myth About Plasma Donation and Erectile Dysfunction

Some people believe that donating plasma frequently or long-term can cause erectile dysfunction in men due to potential impacts on testosterone levels or other effects. However, there is no scientific evidence to support a direct link between plasma donation and ED. While plasma donation may lead to some temporary changes, such as decreased protein levels, it does not cause any known long-term hormonal or other health effects and will not directly lead to erectile difficulties.

Here are some of the facts around this myth:

  • Plasma donors experience a temporary drop in protein levels after donating due to the removal of plasma, which contains proteins like albumin. However, plasma protein levels return to normal within 24 to 48 hours as the body works to replace the donated plasma. This temporary change does not lead to any long-term hormonal or health impacts.
  • Donating plasma does not cause changes in testosterone or other hormone levels. Testosterone levels remain in the normal range following plasma donation. While a small study found a minor drop in testosterone levels immediately after donation, levels returned to baseline within 24 hours. There were no cumulative impacts on testosterone levels for frequent donors.
  • The needle insertion during donation does not damage blood vessels or nerves involved in erectile function. The needles used during plasma donation do not come into contact with blood vessels related to achieving or maintaining an erection. No nerve damage occurs as a result of plasma donation.
  • Plasma donations provide life-saving plasma protein therapies and a safe process. Plasma donation centers follow strict FDA regulations and screening procedures to ensure the safety of donors and patients receiving plasma treatments. Millions of plasma donations are made safely each year in the U.S. alone, with no evidence of long-term health risks when done properly and according to regulations.
  • Other potential side effects of plasma donation like bruising, fatigue and dizziness are temporary. While some donors may experience discomfort from the needle insertion, these effects subside within a couple of days and are not medically dangerous or life-threatening when following recommended donation frequency. Fainting can sometimes occur in a small percentage of donors but can be avoided by following guidelines on eating and drinking before donating.
  • •There are no reports of ED resulting from plasma donation in medical literature or donor records. If donating plasma directly caused ED or other long-term effects, it would be documented in the many studies on side effects related to plasma donation or reported by the over 38 million people worldwide who have donated plasma. However, there are no such reports.

In summary, while plasma donation may temporarily impact protein levels and cause mild side effects, there is no evidence that it leads to erectile difficulties or other long term health problems. The myth that plasma donation causes ED appears to simply be based on speculation rather than scientific evidence. For most men, the cause of ED is due to other unrelated physical or psychological factors.


ED can be distressing and sometimes difficult to discuss or address. However, understanding the true causes and risk factors is important to finding the right treatment and regaining confidence in one’s health and body. For plasma donors, it may be reassuring to know that there is no proven link between your life-saving donations and erectile difficulties. Donating plasma is considered an extremely safe procedure, as long as proper guidelines are followed regarding frequency and ensuring overall good health before donation.

Plasma donors should feel confident that they are providing a critical lifeline to those in need through their donations and need not worry about myths regarding erectile function. As always, any concerns about one’s health, sexual health, or experiences with plasma donation should be discussed with a medical professional. But on the whole, plasma donation centers remain very safe places to volunteer your time for a good cause.

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